<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6312 6312-30909 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y V75L V106A, G190A F227FL V35I, T39E, E44D, R83K, V118I, D123E, I135T, I142M, K166R, I195L, G196E, Q207E, R211K, A272P, T286A, I293V, E297KR, G333E, Y342YF, R356RK, K366R, A371V, A376S, K390R  
>6312-30909| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICEELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLLDFRELNKKTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNETPGMRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI
YQYVDDLYVASDLELEQHRTKIEELREHLWKWGFYTPDKKHQKEPPLLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIFQEPFKNLKTGKYAKMRGA
HTNDVRQLTEVVQKISTESIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V82VA   T12S, K14KR, I15V, I62IV, L63LP, V77I  
>6312-30909| codons 1-99
PQITLWQRPLVSIRVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QVPIEICGHKAIGTVLIGPTPANIIGRNLLTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006