Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6310 | 6310-30911 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V, T215F | K219Q, N348I | Y181C | V108I | V35L, V118VI, D123E, I135T, T139K, V179I, G196E, F214FL, D218E, L228H, I244V, A272P, K281KR, I293V, P294S, E297K, I341IF, R356RKQ, G359GS, A371V, I375V, A376T |
| >6310-30911| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSTNNEKPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII CQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGLFTPEQKHQKEPPFHWMGYELHPDKWT VQPVVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVVSLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQFYQEPFKILKTGKYAQMRSA HTNDVKQLTEVVQKVTTESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54S, V82A, L90M | L33F, K43T | L10V, I13V, L19I, E35D, M36I, K55R, L63P, A71V, T74S, I93L |
| >6310-30911| codons 1-99 PQITLWQRPVVTVKIGGQIKEALLDTGADDTVFEDINLPGRWTPKIIGGIGGFSRVRQYD QIPIEICGHKVIGSVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |