Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6308 | 6308-30924 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215CY | A98G | S68G, K122E, V179I, R211K, K249Q, A272P, K281R, T286A, E297K, Q334E, V381I, T386TI, K390KR, E396D |
| >6308-30924| codons 2-399 ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPVF AIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPLD EDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIIIY QYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWTV QPIVLPEQDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGAKALTEVIPLTKEAEL ELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMRGAH TNDVKQLTEAVQKIATESIIIWGKIPKFRLPIQKDTWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | Q58E, N88D | L10I, I15V, G16A, K20R, E35D, M36I, N37ND, R57K, I62V, L63P, A71V, T91S |
| >6308-30924| codons 1-99 PQITLWQRPIVTIKVAGQLREALLDTGADDTVLEDIDLPGRWKPKIIGGIGGFVKVKEYD QVPIEICGHKVIGTVLVGPTPANIIGRDLMSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |