Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
48-6306 | 6306-30918 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | PI|NRTI|NNRTI | NA |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
M184V, T215Y | G190A | K101H | K49R, R83K, I135T, S162A, E169D, V179I, G196E, E203D, V245E, A272P, K277R, T286P, I293V, E297A, I326V, I329V, Q334E, R356K, S379C |
>6306-30918| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILDPFRKQNPDIII YQYVDDLYVASDLEIEQHRTKIDELRQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGPKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLVAEVQKQGEGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVKQLTEAVQKIATECIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
I54V, V82A | L33I | L10V, I13V, K20I, M36I, P39S, D60E, I64V, A71V, V75I, I93L |
>6306-30918| codons 1-99 PQITLWQRPVVTVKIGGQLIEALLDTGADDTVIEEINLSGRWKPKMIGGIGGFVKVRQYE QILVEICGHKVIGTILVGPTPANIIGRNLLTQLGCTLNF |
References
Author | Title | Citation |
Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |