Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6306 | 6306-30918 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L33I | L10V, I13V, K20I, M36I, P39S, D60E, I64V, A71V, V75I, I93L |
| >6306-30918| codons 1-99 PQITLWQRPVVTVKIGGQLIEALLDTGADDTVIEEINLSGRWKPKMIGGIGGFVKVRQYE QILVEICGHKVIGTILVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V, T215Y | G190A | K101H | K49R, R83K, I135T, S162A, E169D, V179I, G196E, E203D, V245E, A272P, K277R, T286P, I293V, E297A, I326V, I329V, Q334E, R356K, S379C |
| >6306-30918| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILDPFRKQNPDIII YQYVDDLYVASDLEIEQHRTKIDELRQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGPKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLVAEVQKQGEGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVKQLTEAVQKIATECIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |