<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6305 6305-30917 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, V75M, M184V, L210W, T215Y   G190A K101H E44D, K49R, V60I, K64KR, A98S, K122KE, S162D, S163SG, E169D, Q207E, R211K, I244IV, V245E, A272AT, I293V, P294T, E297K, G359S, A371V, K390R  
>6305-30917| codons 1-398
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISRIGPENPYNTPI
FAIRKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPSGLHKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDGMTKILDPFRKQNPDIVI
YQYVDDLYVASDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPVELPEKDSWTVNDIQKLVGKLNWASQIYTGIKVKQLCKLLRGTKALTEVVTLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETW

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, I84V, L90M V11VI, L33IV, K43KT L10I, I13V, K20I, M36MI, L63P, A71V, I72L  
>6305-30917| codons 1-99
PQITLWQRPIITVKIGGQLIEALLDTGADDTVVEEINLPGRWTPKLIGGIGGFVKVRQYD
QIPIEICGHKVLGTVLVGPTPANVIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006