Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6305 | 6305-30917 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V, L90M | V11VI, L33IV, K43KT | L10I, I13V, K20I, M36MI, L63P, A71V, I72L |
| >6305-30917| codons 1-99 PQITLWQRPIITVKIGGQLIEALLDTGADDTVVEEINLPGRWTPKLIGGIGGFVKVRQYD QIPIEICGHKVLGTVLVGPTPANVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | G190A | K101H | E44D, K49R, V60I, K64KR, A98S, K122KE, S162D, S163SG, E169D, Q207E, R211K, I244IV, V245E, A272AT, I293V, P294T, E297K, G359S, A371V, K390R |
| >6305-30917| codons 1-398 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISRIGPENPYNTPI FAIRKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPSGLHKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDGMTKILDPFRKQNPDIVI YQYVDDLYVASDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPVELPEKDSWTVNDIQKLVGKLNWASQIYTGIKVKQLCKLLRGTKALTEVVTLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETW |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |