Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6304 | 6304-30910 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47A, I84V | L10V, I13V, I15V, G16GE, K20I, R41K, H69K, T74A, V77I, L89M |
| >6304-30910| codons 1-99 PQITLWQRPVVTVKVEGQLIEALLDTGADDTVLEEMNLPGKWKPKIAGGIGGFIKVRQYD QILIEICGKKAIGAVLIGPTPVNVIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, T215Y | K219Q | Y188L | V35T, K43N, V60I, K122KE, D123AE, I135T, K166R, D177E, G196E, H208Y, R211K, D218E, H221Y, L228LH, A272P, V276T, K277R, K281R, L283I, E297K, R356RK, M357MV, G359S, K395R, E396D |
| >6304-30910| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELENEGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVI YQYVDDLLVGSDLEIEQHRTKIEELRQYLLKWGFYTPEQKYQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKTRQLCRLIRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKVRSA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQRDTWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |