<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6304 6304-30910 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47A, I84V   L10V, I13V, I15V, G16GE, K20I, R41K, H69K, T74A, V77I, L89M  
>6304-30910| codons 1-99
PQITLWQRPVVTVKVEGQLIEALLDTGADDTVLEEMNLPGKWKPKIAGGIGGFIKVRQYD
QILIEICGKKAIGAVLIGPTPVNVIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, T215Y K219Q Y188L   V35T, K43N, V60I, K122KE, D123AE, I135T, K166R, D177E, G196E, H208Y, R211K, D218E, H221Y, L228LH, A272P, V276T, K277R, K281R, L283I, E297K, R356RK, M357MV, G359S, K395R, E396D  
>6304-30910| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELENEGKISKIGPENPYNTPI
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVI
YQYVDDLLVGSDLEIEQHRTKIEELRQYLLKWGFYTPEQKYQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKTRQLCRLIRGTKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKVRSA
HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQRDTWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006