Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6299 | 6299-30912 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K219R | V106A, G190A | F227L | E6K, K20R, T39K, K43E, E44D, V60I, V90I, K102N, V118I, K122E, D123E, I142V, Q174K, V179I, G196E, T200A, E203D, R211K, D218E, A272P, T286A, E297R, D324E, M357V, R358K, A376V, S379C, T386A, K390R, E396D |
| >6299-30912| codons 1-399 PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICKELEEDGKISKIGPENPYNTPI FAIKKKNSTKWRKLMDFRELNKRTQDFWEIQLGIPHPAGLKNKKSATVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIII YQYVDDLYVASDLEIEQHRAKIDELRQHLWKWGFYTPERKHQKEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARVKGA HTNDVKQLTEAVQKIVTECIVIWGKAPKFRLPIQKDTWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, G48L, I54T, V82A, L90M | V11I | L10V, T12P, I13V, K14R, I15V, G16E, K20I, M36I, F53Y, L63T, I64V, H69K, A71I, T74S, I93L |
| >6299-30912| codons 1-99 PQITLWQRPVIPVRVEGQLIEALLDTGADDTVLEEINLPGRWKPKIVLGIGGYTKVRQYD QITVEICGKKIIGSVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |