<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6299 6299-30912 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, G48L, I54T, V82A, L90M V11I L10V, T12P, I13V, K14R, I15V, G16E, K20I, M36I, F53Y, L63T, I64V, H69K, A71I, T74S, I93L  
>6299-30912| codons 1-99
PQITLWQRPVIPVRVEGQLIEALLDTGADDTVLEEINLPGRWKPKIVLGIGGYTKVRQYD
QITVEICGKKIIGSVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, V75M, M184V, L210W, T215Y K219R V106A, G190A F227L E6K, K20R, T39K, K43E, E44D, V60I, V90I, K102N, V118I, K122E, D123E, I142V, Q174K, V179I, G196E, T200A, E203D, R211K, D218E, A272P, T286A, E297R, D324E, M357V, R358K, A376V, S379C, T386A, K390R, E396D  
>6299-30912| codons 1-399
PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICKELEEDGKISKIGPENPYNTPI
FAIKKKNSTKWRKLMDFRELNKRTQDFWEIQLGIPHPAGLKNKKSATVLDVGDAYFSIPL
DEEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIII
YQYVDDLYVASDLEIEQHRAKIDELRQHLWKWGFYTPERKHQKEPPLLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTREAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARVKGA
HTNDVKQLTEAVQKIVTECIVIWGKAPKFRLPIQKDTWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006