Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6294 | 6294-30930 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L24I | L10I, T12P, K14R, K20R, E35D, M36I, N37D, I62IV, L63P, A71V, T74S |
| >6294-30930| codons 1-99 PQITLWQRPIVPIRIGGQLREALIDTGADDTVLEDIDLPGRWKPKMIGGIGGFVKVRQYD QVPIEICGHKVIGSVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, M184V, T215F | K219Q | K103KN | V60I, V118VI, D123E, I135T, D177E, G196E, T200I, Q207E, R211K, I244IV, A272P, T296S, E297K, E312ED, M357T, K390R, Q394T, K395KR, E396D, E399D |
| >6294-30930| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIEQHRIKIEELREHLLKWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPVVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLSKEAE LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPITRDTWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |