Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6293 | 6293-30910 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | F53L, G73T | L10V, T12K, I15V, G16E, L19P, K20I, E34Q, M36I, K45KR, Q61H, L63S, H69K |
| >6293-30910| codons 1-99 PQITLWQRPVVKIKVEGQPIEALLDTGADDTVLQEINLPGRWKPRLIGGIGGLVKVRQYD HISIEICGKKAITTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, Q151M, M184V | T215I, K219Q | V108I | K22R, V35T, V60I, W88CS, D123E, I135L, I178L, V179VI, I202IV, R211RT, F214L, A272P, K281R, E297R, I329V, V365I, T386I |
| >6293-30910| codons 1-399 PISPIETVPVKLKPGMDGPKVRQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPI FAIKKKNSDKWRKLVDFRELNKRTQDFSEVQLGIPHPAGLKKKKSVTILDVGDAYFSVPL DKEFRKYTAFTIPSLNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDLII YQYVDDLYVGSDLEIGQHRTKVEELRQHLLTWGLITPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDIKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |