<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6292 6292-30910 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74V, M184V, L210W, T215Y   L100I, K103N   V35M, E44D, V118I, K122E, D123DE, K166R, V179I, G196E, T200A, E203K, R211D, V245M, E248N, D250E, A272P, I293V, E297K, G335GS, A360T, K366R, A371V, A376S, E399D  
>6292-30910| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKDGKISKIGPENPYNTPV
FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIII
YQYVDDLYVGSDLEIEQHRAKIKELRQHLWDWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIMLPNKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQSQWTYQIYQEPFKNLKTGKYARMRGT
HTNDVRQLTEVVQKISTESIVIWGKTPKFKLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46MI, I47IV, I54AV, V82S L24I, L33F, F53FL L10I, I13V, E34Q, D60E, I62V, L63Q, I64IV, I66F, A71V, T74E, V77I, T91TA, I93IV  
>6292-30910| codons 1-98
PQITLWQRPIVTVKIGGQLKEALIDTGADDTVFQEMNLPGRWKPKIVGGIGGLVKVRQYE
QVQVEFCGHKVIGEVLIGPTPSNIIGRNLLAQVGCTLN

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006