Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6292 | 6292-30910 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I47IV, I54AV, V82S | L24I, L33F, F53FL | L10I, I13V, E34Q, D60E, I62V, L63Q, I64IV, I66F, A71V, T74E, V77I, T91TA, I93IV |
| >6292-30910| codons 1-98 PQITLWQRPIVTVKIGGQLKEALIDTGADDTVFQEMNLPGRWKPKIVGGIGGLVKVRQYE QVQVEFCGHKVIGEVLIGPTPSNIIGRNLLAQVGCTLN |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | L100I, K103N | V35M, E44D, V118I, K122E, D123DE, K166R, V179I, G196E, T200A, E203K, R211D, V245M, E248N, D250E, A272P, I293V, E297K, G335GS, A360T, K366R, A371V, A376S, E399D |
| >6292-30910| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIII YQYVDDLYVGSDLEIEQHRAKIKELRQHLWDWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPNKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQSQWTYQIYQEPFKNLKTGKYARMRGT HTNDVRQLTEVVQKISTESIVIWGKTPKFKLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |