<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6288 6288-30924 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54M, V82A, L90M L33LF, L89V I13V, K20R, E35ED, M36I, N37D, I62V, L63P, A71IV, I72V  
>6288-30924| codons 1-99
PQITLWQRPLVTVKIGGQLREALLDTGADDTIFEDIDLPGRWKPKIVGGIGGFMKVRQYD
QVPIEICGHKVVGTVLVGPTPANIIGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, L210W, T215Y   K103N, Y188L   K20R, T27TS, V35IM, E40X, K43E, E44ED, K49R, V90VI, A98S, V118I, D123E, E138AS, E169K, K173E, I178IM, V179I, G196E, T200A, E203K, Q207E, H208HY, K223KE, E224EK, A272P, K281R, T286P, E297R, K311R, D324E, Q334P, G335D, R356K, M357T, G359GS, A360IT, A376T, T386A, A400T T39T*KS
>6288-30924| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLSEEKIKALMEICSXLEEDGKISRIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEIQLGIPHPSGLKKNKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSINNSTPGIRYQYNVLPQGWKGSPAIFQSSMTKILKPFREQNPDMII
YQYVDDLLVGSDLEIEQHRAKIKELREYLWRWGFYTPDKKHQEKPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGPKALTEVIPLTREAE
LELAENREILREPVHGVYYDPSKELIAEIQKQGPDQWTYQIYQEPFKNLKTGKYAKTRST
HTNDVKQLTEAVQKITTESIVIWGKAPKFKLPIQKETWET

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006