Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6287 | 6287-30828 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82A | Q58E | L10I, G17D, L19I, K20R, E34Q, E35D, M36I, N37D, I62V, L63P, A71T, V77L |
| >6287-30828| codons 1-99 PQITLWQRPIVTIKIGDQIREALLDTGADDTVLQDIDLPGRWKPKMIVGIGGFTKVREYD QVPIEICGHKTIGTVLLGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, M184V, T215F | K219Q | T39TA, K46KQ, T69N, K122E, I135T, S162C, D177E, T200A, D218E, L228H, V245L, A272P, K277R, A288S, I293V, E297A, Q334L, G359S, T369V, S379G, T386I, K390R |
| >6287-30828| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGQISKIGPENPYNTPV FAIKKKNSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGFFTPEQKHQKEPPFHWMGYELHPDKWT VQPILLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKSLTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLVEAVQKIATEGIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |