<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6286 6286-30820 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L210W, T215Y K219R K101E, Y181C, G190A V108I V35I, T39E, E44D, L109I, V118I, K122E, D123N, I135T, S162D, E169K, K173Q, G196E, I202V, E203K, Q207E, R211K, H221Y, V245E, A272P, K277R, L283I, V292I, I293V, E297K, E312Q, R356K, G359S, A371V, T386I  
>6286-30820| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICEELEKDGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTIIDVGDAYFSIPL
DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILKPFRQQNPDIVI
CQYMDDLYVASDLEIEQHRTKVKELREHLWKWGFYTPDRKYQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEIVPLTKEAE
LELAENREILKQPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVKQLTEVVQKIATESIVIWGKIPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54S, V82A, I84V L33I, Q58E L10I, I13V, Q18H, K20M, M36I, I62V, L63P, I64V, T74S  
>6286-30820| codons 1-99
PQITLWQRPIVTVKIGGHLMEALLDTGADDTVIEEINLPGRWKPKMIVGIGGFSKVREYD
QVPVEICGHKAIGSVLVGPTPANVIGRNLLTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006