Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6286 | 6286-30820 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54S, V82A, I84V | L33I, Q58E | L10I, I13V, Q18H, K20M, M36I, I62V, L63P, I64V, T74S |
| >6286-30820| codons 1-99 PQITLWQRPIVTVKIGGHLMEALLDTGADDTVIEEINLPGRWKPKMIVGIGGFSKVREYD QVPVEICGHKAIGSVLVGPTPANVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K219R | K101E, Y181C, G190A | V108I | V35I, T39E, E44D, L109I, V118I, K122E, D123N, I135T, S162D, E169K, K173Q, G196E, I202V, E203K, Q207E, R211K, H221Y, V245E, A272P, K277R, L283I, V292I, I293V, E297K, E312Q, R356K, G359S, A371V, T386I |
| >6286-30820| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICEELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTIIDVGDAYFSIPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILKPFRQQNPDIVI CQYMDDLYVASDLEIEQHRTKVKELREHLWKWGFYTPDRKYQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEIVPLTKEAE LELAENREILKQPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEVVQKIATESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |