Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6279 | 6279-30826 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L74V, L210W, T215Y | K219R, N348I | L100I, K103N | E6D, K20R, V35M, T39TA, K43KDEN, E44AD, V118I, K122E, D123E, K166R, D177N, V179I, T200A, E203V, Q207E, H208Y, R211K, E224D, L228R, V245E, S251SR, K277R, T286A, I293V, P294T, E297K, R356K, G359S, A376T, T377Q, T386A, K390R, A400S |
| >6279-30826| codons 1-400 PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALMEICAELENDGKISKIGPENPYNTPV FAIKKKDSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPNIII YQYMDDLYVGSDLEIGQHRAKIVELREYLWKWGFYTPDRKHQKDPPFRWMGYELHPDKWT VQPIELPEKDRWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVVTLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYAKMRSA HTNDVKQLTEAVQKITQESIVIWGKAPKFRLPIQKETWES |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I47V, G48M, I54M, V82A, I84V | V11I, Q58E | L10I, I15V, L19P, K20I, A22V, E34Q, M36I, Q61H, I62V, L63P, A71I, I72T, I85V, I93L | D60DANT |
| >6279-30826| codons 1-99 PQITLWQRPIITIKVGGQPIEVLLDTGADDTVLQEINLPGRWKPKMVMGIGGFMKVREYT HVPIEICGHKITGTVLVGPTPANVVGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |