<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6279 6279-30826 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, L74V, L210W, T215Y K219R, N348I L100I, K103N   E6D, K20R, V35M, T39TA, K43KDEN, E44AD, V118I, K122E, D123E, K166R, D177N, V179I, T200A, E203V, Q207E, H208Y, R211K, E224D, L228R, V245E, S251SR, K277R, T286A, I293V, P294T, E297K, R356K, G359S, A376T, T377Q, T386A, K390R, A400S  
>6279-30826| codons 1-400
PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALMEICAELENDGKISKIGPENPYNTPV
FAIKKKDSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPNIII
YQYMDDLYVGSDLEIGQHRAKIVELREYLWKWGFYTPDRKHQKDPPFRWMGYELHPDKWT
VQPIELPEKDRWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVVTLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYAKMRSA
HTNDVKQLTEAVQKITQESIVIWGKAPKFRLPIQKETWES

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I47V, G48M, I54M, V82A, I84V V11I, Q58E L10I, I15V, L19P, K20I, A22V, E34Q, M36I, Q61H, I62V, L63P, A71I, I72T, I85V, I93L D60DANT
>6279-30826| codons 1-99
PQITLWQRPIITIKVGGQPIEVLLDTGADDTVLQEINLPGRWKPKMVMGIGGFMKVREYT
HVPIEICGHKITGTVLVGPTPANVVGRNLLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006