Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6276 | 6276-30826 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K219N | Y188L | V8I, V35M, K43Q, E44D, K102M, V118I, K122E, I135T, T165I, Q174R, I202V, Q207E, H208Y, R211K, L228H, A272P, K277R, L283I, I293V, R358RK, K366R, T386I, K390KR, K395R, E399D |
| >6276-30826| codons 1-399 PISPIETIPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEQDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKMKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKRNPDIVI YQYMDDLLVGSDLEIGQHRTKVEELREYLWKWGFYTPDNKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKGA HTNDVRQLTEAVQKIATESIVIWGKIPKFRLPIQRETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47A, I84V, L90M | V11I | L10I, I15V, L19Q, K20I, N37D, K45R, R57K, I62V, L63P, A71V, I72R, I85V, I93L |
| >6276-30826| codons 1-99 PQITLWQRPIITIKVGGQQIEALLDTGADDTVLEEMDLPGRWKPRIAGGIGGFIKVKQYD QVPIEICGHKVRGTVLVGPTPVNVVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |