<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6276 6276-30826 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47A, I84V, L90M V11I L10I, I15V, L19Q, K20I, N37D, K45R, R57K, I62V, L63P, A71V, I72R, I85V, I93L  
>6276-30826| codons 1-99
PQITLWQRPIITIKVGGQQIEALLDTGADDTVLEEMDLPGRWKPRIAGGIGGFIKVKQYD
QVPIEICGHKVRGTVLVGPTPVNVVGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L210W, T215Y K219N Y188L   V8I, V35M, K43Q, E44D, K102M, V118I, K122E, I135T, T165I, Q174R, I202V, Q207E, H208Y, R211K, L228H, A272P, K277R, L283I, I293V, R358RK, K366R, T386I, K390KR, K395R, E399D  
>6276-30826| codons 1-399
PISPIETIPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEQDGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKMKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKRNPDIVI
YQYMDDLLVGSDLEIGQHRTKVEELREYLWKWGFYTPDNKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKGA
HTNDVRQLTEAVQKIATESIVIWGKIPKFRLPIQRETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006