Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6274 | 6274-30923 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | K103N, Y181C | T39A, D123E, I135IT, I142V, Q174QR, T200A, R211A, L228H, A272P, Q278QHKN, I293V, E297R, V317A, S322T, M357T, K366R |
| >6274-30923| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI CQYVDDLYVGSDLEIGQHRAKIEELRQHLLAWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKNLCKLLRGTKALTEVVPLTREAE LELAENREILKEPVHGAYYDPTKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVRQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, V82A, L90M | G73S | L10I, I15V, L19LP, K20M, E35D, M36I, K45R, I62V, L63P, A71V, I72LM, I85V |
| >6274-30923| codons 1-99 PQITLWQRPIVTIKVGGQPMEALLDTGADDTVLEDINLPGRWKPRMIGGIGGFLKVRQYD QVPIEICGHKVMSTVLVGPTPANIVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |