Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6273 | 6273-30923 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | Q58E | L10I, M36MI, K55KR, I62V, L63S, I64MV |
| >6273-30923| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVRVREYD QVSVEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T215F | K219Q | D123E, I135L, K166R, D177E, I195IL, G196E, A272P, K275R, K277R, T286A, I293V, E297K, Q334H, A360T, K366R, T369V, A371V, I375V, A376T, K390R, K395R, E399D |
| >6273-30923| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVI YQYMDDLYVGSDLELEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGAKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHGQWTYQIYQEPFKNLKTGKYARMRGT HTNDVRQLVEVVQKVTTESIVIWGKTPKFRLPIQRETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |