<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6272 6272-30910 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L210W, T215Y A62V, V75I, K219KN, N348NI K103N, M230L L234I, Y318F V90VI, V106VI, K122E, D123E, I135T, S162Y, T200TA, V245VA, A272P, T286A, A288T, I293V, P294PS, E297R, V317A, A376S, Q394L  
>6272-30910| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FVIKKKDSTKWRKLIDFRELNKRTQDFWEIQLGIPHPAGLKKNKSITVLDVGDAYFSVPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRAKIEELRQHLWRWGFYTPDNKHQKEPPFLWLGYEIHPDKWT
VQPIALPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKTLTEVVSLTREAE
LELAENREILKEPVHGAFYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYARMRGA
HTNDVKQLTEAVQKISTESIVIWGKTPKFKLPILKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, V82T, L90M   T12K, L19IV, N37D, L63P, H69KN, A71AV, I72IV, V77I, T91TN, I93IL, C95CF  
>6272-30910| codons 1-99
PQITLWQRPLVKIKIGGQVKEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFIKVRQYD
QIPIEICGNKVVGTVLIGPTPTNIIGRNLMNQLGFTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006