Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6272 | 6272-30910 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82T, L90M | T12K, L19IV, N37D, L63P, H69KN, A71AV, I72IV, V77I, T91TN, I93IL, C95CF |
| >6272-30910| codons 1-99 PQITLWQRPLVKIKIGGQVKEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGNKVVGTVLIGPTPTNIIGRNLMNQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | A62V, V75I, K219KN, N348NI | K103N, M230L | L234I, Y318F | V90VI, V106VI, K122E, D123E, I135T, S162Y, T200TA, V245VA, A272P, T286A, A288T, I293V, P294PS, E297R, V317A, A376S, Q394L |
| >6272-30910| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FVIKKKDSTKWRKLIDFRELNKRTQDFWEIQLGIPHPAGLKKNKSITVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLWRWGFYTPDNKHQKEPPFLWLGYEIHPDKWT VQPIALPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKTLTEVVSLTREAE LELAENREILKEPVHGAFYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYARMRGA HTNDVKQLTEAVQKISTESIVIWGKTPKFKLPILKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |