Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6266 | 6266-30917 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48ILM, I54V, V82A, L90M | L33LF, F53L | L10IV, I13IL, L19I, K20KR, M36MI, K55R, R57RK, I62V, L63PS, I64M, A71I, I93L |
| >6266-30917| codons 1-99 PQITLWQRPVVTLKIGGQIREALLDTGADDTVFEEINLPGRWKPKMIMGIGGLVRVKQYD QVSMEICGHKIIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219E | K103N, Y181C | K101H | K20R, V35L, I135T, I178L, T200V, R211K, D218E, L228H, V245VE, D250DE, K277R, A288S, I293V, P294T, E312EQ, Q334N, M357T, R358K, E370Q, K390R, K395R |
| >6266-30917| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLHKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI CQYVDDLYVGSDLEIGQHRVKIEELRQHLLKWGFFTPEEKHQKEPPFHWMGYELHPDKWT VQPIELPEKESWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKSLTEVVTLTEEAE LELAENREILKQPVHGVYYDPSKDLIAEIQKQGNGQWTYQIYQEPFKNLKTGKYARTKGA HTNDVKQLTQAVQKIATESIVIWGKTPKFRLPIQRETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |