<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6266 6266-30917 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48ILM, I54V, V82A, L90M L33LF, F53L L10IV, I13IL, L19I, K20KR, M36MI, K55R, R57RK, I62V, L63PS, I64M, A71I, I93L  
>6266-30917| codons 1-99
PQITLWQRPVVTLKIGGQIREALLDTGADDTVFEEINLPGRWKPKMIMGIGGLVRVKQYD
QVSMEICGHKIIGTVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, M184V, T215F K219E K103N, Y181C K101H K20R, V35L, I135T, I178L, T200V, R211K, D218E, L228H, V245VE, D250DE, K277R, A288S, I293V, P294T, E312EQ, Q334N, M357T, R358K, E370Q, K390R, K395R  
>6266-30917| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLHKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI
CQYVDDLYVGSDLEIGQHRVKIEELRQHLLKWGFFTPEEKHQKEPPFHWMGYELHPDKWT
VQPIELPEKESWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKSLTEVVTLTEEAE
LELAENREILKQPVHGVYYDPSKDLIAEIQKQGNGQWTYQIYQEPFKNLKTGKYARTKGA
HTNDVKQLTQAVQKIATESIVIWGKTPKFRLPIQRETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006