Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6265 | 6265-30806 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | V75L | K101E, G190S | T39TA, K43E, E44A, V106I, V118I, D123E, V179VG, G196E, R211K, A272P, K281R, E291D, P294S, E297K, I326V, Q334E, R356K, T369V, A376T |
| >6265-30806| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEEAGKISKIGPENPYNTPV FAIKKKNSDKWRKLLDFRELNKRTQDFWEVQLGIPHPAGLEKKKSITVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIGI YQYMDDLYVSSDLEIEQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTDVISLTKEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGEGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVKQLVEAVQKITTESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82F | L33F, Q58E | L10IV, E35D, M36I, N37S, R41K, R57K, Q61E, I62V, L63P, L89M |
| >6265-30806| codons 1-99 PQITLWQRPVVTIKIGGQLKEALLDTGADDTVFEDISLPGKWKPKMIGGIGGFVKVKEYD EVPIEICGHKAIGTVLVGPTPFNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |