Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6263 | 6263-30929 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82VA | I15V, G16E, M36MI, N37ND, I62V, L63Q, I72V |
| >6263-30929| codons 1-99 PQITLWQRPLVTIKVEGQLKEALLDTGADDTVLEEIDLPGRWKPKMIGGIGGFIKVRQYD QVQIEICGHKAVGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T215TI | K103NS, Y181YFIN | E6D, V35L, T39A, K43KE, E53D, R83K, I178M, R211K, A272P, V317A, R356K, G359S |
| >6263-30929| codons 1-399 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALLEICAEMEEEGKISKIGPDNPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI NQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFITPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |