Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6262 | 6262-30828 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | N348I | K103N | V35M, T39A, K43E, V60I, V118I, I135T, S162W, D177DN, G196GE, T200A, R211K, L228LH, A272P, F346Y, M357T, D364DE |
| >6262-30828| codons 1-398 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEEEGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQWSMTKILEPFRKQNPNIVI YQYMDDLYVGSDLEIEQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPYKILKTGKYARTRGA HTNEVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10F, L33F | T12P, I15V, G17E, Q18H, K20T, E35D, M36I, N37P, I62V, L63P, I66L, C67F, A71T, I72T, I93L |
| >6262-30828| codons 1-99 PQITLWQRPFVPIKVGEHLTEALLDTGADDTVFEDIPLPGRWKPKMIGGIGGFVKVRQYD QVPIELFGHKTTGTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |