Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6260 | 6260-30828 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | E6D, E28EA, V35I, E44D, S48E, S68G, A98S, D123E, E138A, K166R, I178M, V179I, T200A, E248D, A272P, K277R, E297T, M357S, A360V |
| >6260-30828| codons 1-398 PISPIDTVPVKLKPGMDGPKVKQWPLTAEKIKALIEICTELEKDGKIEKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDMII YQYVDDLYVGSDLEIGQHRAKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTTEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARSRGV HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47A, V82A | K43T | L10I, K20R, M36I, I62V, L63T, I64V, E65D, A71V, I93IL |
| >6260-30828| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTILEEINLPGRWTPKIAGGIGGFIKVRQYD QVTVDICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |