Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6257 | 6257-30909 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A, L90M | L10F, L33F | T12P, I13V, K14R, G16GA, N37D, L63P, H69R, A71T, I93L, C95F |
| >6257-30909| codons 1-99 PQITLWQRPFVPVRIAGQLKEALLDTGADDTVFEEMDLPGRWKPKIIGGIGGFVKVRQYD QIPIEICGRKTIGTVVVGPTPANIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, L210W, T215Y | K219R | V35L, T39K, K43E, E44D, V111I, V118I, K122E, I135T, I142V, I178L, G196E, E203D, H208Y, R211K, K223Q, A272P, T286A, V292I, R356RK, M357MV, R358K, G359S, A371AT |
| >6257-30909| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICKELEEDGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDIGDAYFSIPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYMDDLYVGSDLEIEQHRTKIDELRQYLWKWGFYTPDRKHQQEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEIIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKVKSA HTNDVKQLTETVQKIATESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |