<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6257 6257-30909 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82A, L90M L10F, L33F T12P, I13V, K14R, G16GA, N37D, L63P, H69R, A71T, I93L, C95F  
>6257-30909| codons 1-99
PQITLWQRPFVPVRIAGQLKEALLDTGADDTVFEEMDLPGRWKPKIIGGIGGFVKVRQYD
QIPIEICGRKTIGTVVVGPTPANIIGRNLMTQLGFTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, L210W, T215Y K219R     V35L, T39K, K43E, E44D, V111I, V118I, K122E, I135T, I142V, I178L, G196E, E203D, H208Y, R211K, K223Q, A272P, T286A, V292I, R356RK, M357MV, R358K, G359S, A371AT  
>6257-30909| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICKELEEDGKISKIGPENPYNTPV
FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDIGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI
YQYMDDLYVGSDLEIEQHRTKIDELRQYLWKWGFYTPDRKHQQEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEIIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKVKSA
HTNDVKQLTETVQKIATESIVIWGKTPKFKLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006