Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6252 | 6252-30730 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K219KR | A98G | K20R, V35I, T39A, K43Q, E44D, V118I, D123E, G196E, T200A, H208Y, R211K, K223Q, L228H, Q242QL, A272P, K281KR, A288S, E297K, L301M, S322T, R356K, G359S, A360T, A376S, T386I, Q394L | E203N |
| >6252-30730| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICAELEQDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRAKINELRQYLWKWGFYTPDRKHQQEPPFHWMGYELHPDKWT VLPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKSLTEVIPLTKEAE MELAENREILKEPVHGVYYDPTKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRST HTNDVKQLTEAVQKISTESIVIWGKIPKFKLPILKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54A, V82F, L90M | L10I, K20R, E35D, M36I, N37D, L63P, I64V, A71V, I72V, I93L |
| >6252-30730| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIDLPGRWKPKIVGGIGGFAKVRQYD QIPVEICGHKVVGTVLVGPTPFNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |