Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6251 | 6251-30820 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 3 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74I, M184V, L210W, T215Y | K101E, G190GS | E28K, V35VE, T39A, K43E, E44A, S48T, V90I, A98S, V106VI, V118I, K122E, D123E, I135T, N175H, D177E, T200A, K201I, H208Y, R211K, V245T, A272P, V292I, I293V, E297R, Y339W, M357V, T386I |
| >6251-30820| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALEEICAELEEAGKITKIGPENPYNTPV FAIKKKNSDKWRKIVDFRELNKRTQDFWEIQLGIPHPSGLEKKKSITVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQHPEIVI YQYVDDLYVSSDLEIGQHRAIIEELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTWQIYQEPFKNLKTGKYARVRGA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54AFSV, V82AT, I84IV, L90M | Q58E, G73S | L10I, I15V, L19Q, K20I, E34EQ, M36I, N37D, L63P, C67F, H69K, A71V, I85IV, L89LI |
| >6251-30820| codons 1-99 PQITLWQRPIVTIKVGGQQIEALLDTGADDTVLQEIDLPGRWKPKIIGGIGGFVKVREYD QIPIEIFGKKVISTVLVGPTPTNVVGRNIMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |