<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6251 6251-30730 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54A, V82AT, I84IV, L90M Q58E, G73S L10I, I15V, L19Q, K20I, E34EQ, M36I, N37D, L63P, C67F, H69K, A71V, I85IV  
>6251-30730| codons 1-99
PQITLWQRPIVTIKVGGQQIEALLDTGADDTVLQEIDLPGRWKPKIIGGIGGFAKVREYD
QIPIEIFGKKVISTVLVGPTPTNVVGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74I, M184V, L210W, T215Y   K101E, G190GS   E28K, V35VE, T39A, K43E, E44A, S48T, V90I, A98S, V106VI, V118I, K122E, D123E, I135T, N175H, D177E, T200A, K201I, H208Y, R211K, V245T, A272P, V292I, I293V, E297R, Y339W, M357V, T386I  
>6251-30730| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALEEICAELEEAGKITKIGPENPYNTPV
FAIKKKNSDKWRKIVDFRELNKRTQDFWEIQLGIPHPSGLEKKKSITVLDVGDAYFSIPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQHPEIVI
YQYVDDLYVSSDLEIGQHRAIIEELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIVPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTWQIYQEPFKNLKTGKYARVRGA
HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006