Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6249 | 6249-30929 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, Q151M, T215F | V75VI, F77L, F116Y, K219Q | Y188L | K20R, V35M, T39A, T69N, K104N, I135V, Q145V, V179VI, I202V, A272P, K277R, T286A, A288S, E297K, S322A, Q334DN, R356K, M357V, G359GS, V365I, E370D, T386I |
| >6249-30929| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICAEMEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYYSVPL DKDFRKYTAFTIPSVNNETPGIRYVYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYMDDLLVGSDLEIGQHRTKVEELRQHLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKSLTEVIPLTKEAE LELAENREILKEPVHGVYYDPAKDLIAEIQKQGNGQWTYQIYQEPFKNLKTGKYAKVRSA HTNDIKQLTDAVQKIATESIVIWGKIPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82A | L10FV, L33LF, K43T | I15V, G16E, K20M, E34EQ, M36V, I62IMV, L63T, I72T, T74A, L89M |
| >6249-30929| codons 1-99 PQITLWQRPVVTIKVEGQLMEALLDTGADDTIFQEVNLPGRWTPKIVGGIGGFMKVRQYD QVTIEICGHKATGAVLVGPTPANIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |