<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6249 6249-30929 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54M, V82A L10FV, L33LF, K43T I15V, G16E, K20M, E34EQ, M36V, I62IMV, L63T, I72T, T74A, L89M  
>6249-30929| codons 1-99
PQITLWQRPVVTIKVEGQLMEALLDTGADDTIFQEVNLPGRWTPKIVGGIGGFMKVRQYD
QVTIEICGHKATGAVLVGPTPANIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, Q151M, T215F V75VI, F77L, F116Y, K219Q Y188L   K20R, V35M, T39A, T69N, K104N, I135V, Q145V, V179VI, I202V, A272P, K277R, T286A, A288S, E297K, S322A, Q334DN, R356K, M357V, G359GS, V365I, E370D, T386I  
>6249-30929| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICAEMEKEGKISKIGPENPYNTPV
FAIKKKNSNRWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYYSVPL
DKDFRKYTAFTIPSVNNETPGIRYVYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIII
YQYMDDLLVGSDLEIGQHRTKVEELRQHLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKSLTEVIPLTKEAE
LELAENREILKEPVHGVYYDPAKDLIAEIQKQGNGQWTYQIYQEPFKNLKTGKYAKVRSA
HTNDIKQLTDAVQKIATESIVIWGKIPKFKLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006