<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6247 6247-30929 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I50V, I54V, V82T L10F, L89V I13V, L19V, K20I, L33L_L, M36I, K55KR, I62V, L63P, I66F, A71V, I72IT, G73D, Q92K  
>6247-30929| codons 1-99
PQITLWQRPFVTVKIGGQVIEALLDTGADDTVLEEINLPGRWKPKIIGGVGGFVRVRQYD
QVPIEFCGHKVTDTVLVGPTPTNIIGRNVLTKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, L210W, T215Y   Y181YFIN   E6D, V35M, T39A, E44D, V118I, I135IL, S162D, D177E, V179VI, G196E, E203D, Q207E, H208HY, R211K, S251T, A272P, T286A, P294Q, E297R, Q334E, M357T, A371V, A376T, T377L, T386A, K390R, K395R, E396D, E399D  
>6247-30929| codons 1-399
PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKDGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPEIII
NQYVDDLYVGSDLEIEQHRTKIDELREYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDTWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIQLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARTRGA
HTNDVKQLTEVVQKITLESIVIWGKAPKFRLPIQRDTWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006