Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6247 | 6247-30929 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82T | L10F, L89V | I13V, L19V, K20I, L33L_L, M36I, K55KR, I62V, L63P, I66F, A71V, I72IT, G73D, Q92K |
| >6247-30929| codons 1-99 PQITLWQRPFVTVKIGGQVIEALLDTGADDTVLEEINLPGRWKPKIIGGVGGFVRVRQYD QVPIEFCGHKVTDTVLVGPTPTNIIGRNVLTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | Y181YFIN | E6D, V35M, T39A, E44D, V118I, I135IL, S162D, D177E, V179VI, G196E, E203D, Q207E, H208HY, R211K, S251T, A272P, T286A, P294Q, E297R, Q334E, M357T, A371V, A376T, T377L, T386A, K390R, K395R, E396D, E399D |
| >6247-30929| codons 1-399 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPEIII NQYVDDLYVGSDLEIEQHRTKIDELREYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDTWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIQLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEVVQKITLESIVIWGKAPKFRLPIQRDTWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |