Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6246 | 6246-30728 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, Q58E, G73S | T12S, I15V, L19T, K20I, M36I, L63P, C67E, H69K, A71V, N83S |
| >6246-30728| codons 1-99 PQITLWQRPFVSIKVGGQTIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVREYD QIPIEIEGKKVISTVLVGPTPVSVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K32N, V106G, V118I, K122E, I135M, T200A, R211K, A272P, E297Q, D324E, A360T, A371T, K390R |
| >6246-30728| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSGTVLDVGDAYFSIPL DEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTQEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGT HTNDVKQLTETVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |