Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6239 | 6239-30729 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, V82A, L90M | F53L, G73GS | L10I, I15V, M36L, N37D, L38W, I62V, L63P, A71V |
| >6239-30729| codons 1-99 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEELDWPGRWKPKIIGGIGGLVKVRQYD QVPIEICGHKVISTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69T_CT, L74V, L210W, T215Y | D67S | K101P | K20R, K43E, E44A, R83K, A98S, K102Q, V118I, K122E, D123E, I135T, S162D, K166R, I178M, G196E, T200A, R211K, V245E, A272P, E297K, R356RK, K366KR, A376V, T386A, K390KR |
| >6239-30729| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKSSTKWRKVVDFRELNKKTQDFWEVQLGIPHPSGLPQKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQDSMTRILEPFRKQNPDMVI YQYMDDLYVGSDLEIEQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVRQLTEAVQKIVTESIVIWGKAPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |