Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6237 | 6237-30729 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, K70KEGR, L210W, T215Y | K219R | K101E, Y181C, G190GA | V108VI | E28K, K32E, V35I, K43KE, E44ED, L109LV, V118I, K122E, D123E, I135T, R172K, T200A, E203D, Q207E, D218DE, A272P, I293IV, P294A, E297K, Q334E, R358K, G359S, K366R, A376CST, T386TI |
| >6237-30729| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALIEICTELEEDGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTIVDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI CQYMDDLYVASDLEIGQHRAKIDELREHLWRWGFYTPERKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVALTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMKSA HTNDVRQLTEAVQKITTESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | G73S | L10V, I13V, K55R, L63P, C67CY, H69K, A71V, V77I |
| >6237-30729| codons 1-99 PQITLWQRPVVTVKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIRVRQYD QIPIEIYGKKVISTVLIGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |