Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6230 | 6230-30904 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, V75M, M184V, L210W, T215Y | K101P, K103N | A98G | P14S, T39K, K43E, V118I, K122E, K166R, R211K, A272P, K277R, T286A, E297A, M357R, R358K, A371V, I375V, A376S |
| >6230-30904| codons 1-400 PISPIETVPVKLKSGMDGPKVKQWPLTEEKIKALVEICKELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKVMDFRELNKRTQDFWEVQLGIPHPGGLPKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARRKGA HTNDVKQLTEVVQKVSTESIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | L33F, F53L, G73A | L10V, I13V, G16A, E35D, M36I, R41K, D60E, Q61E, L63P, G68E, A71V, I72L |
| >6230-30904| codons 1-99 PQITLWQRPVVTVKIAGQLKEALLDTGADDTVFEDINLPGKWKPKIIGGIGGLIKVRQYE EIPIEICEHKVLATVLVGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |