Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6229 | 6229-30808 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I54S, V82A | L10I, I13V, K20I, M36I, R41K, A71V |
| >6229-30808| codons 1-99 PQITLWQRPIVTVKIGGQLIEALLDTGADDTVLEEINLPGKWKPKMIMGIGGFSKVRQYD QILIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69G_SG | T215C | V35I, S48E, R83K, D123E, I135V, D177E, I178L, V179I, Q207E, V245K, A272P, R284K, T286A, E297K, Q334E, M357T, A360AT, T377R, K395R |
| >6229-30808| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKIEKIGPENPYNTPV FAIKKKDSGKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPELII YQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGFCTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARTRGT HTNDVKQLTEAVQKIARESIVIWGKTPKFKLPIQRETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |