<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6228 6228-30807 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, V75M, M184I, L210W, T215Y K70KQ, F77L     V21VI, V35M, K43KE, E44ED, V118I, D123E, E138A, D177DE, I178M, G196E, Q197EK, T200TA, E203K, H208Y, R211D, K223Q, A272P, K277R, R284K, T286A, E297A, G359S, A376S, S379SC K13KR
>6228-30807| codons 1-399
PISPIETVPVKLRPGMDGPKIKQWPLTEEKIKALMEICTELEEDGKISKIGPENPYNTPV
FAIKKKNSTQWRKLMDLRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI
YQYIDDLYVGSDLEIEKHRAKIKELRQYLWDWGFYTPDKKHQQEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLKGAKALTEVIPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEAVQKISTECIVIWGKTPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46ML, I54V, L76LV, V82VA, I84V, L90M L33F, T74TP L10I, I13V, G16GA, L24LF, E34Q, M36MI, N37NH, R41K, D60DE, I62IV, L63P, A71V, I72IKM, I93L  
>6228-30807| codons 1-99
PQITLWQRPIVTVKIAGQLKEALFDTGADDTVFQEIHLPGKWKPKLIGGIGGFVKVRQYE
QVPIEICGHKVMGPVVVGPTPANVIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006