Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6228 | 6228-30807 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46ML, I54V, L76LV, V82VA, I84V, L90M | L33F, T74TP | L10I, I13V, G16GA, L24LF, E34Q, M36MI, N37NH, R41K, D60DE, I62IV, L63P, A71V, I72IKM, I93L |
| >6228-30807| codons 1-99 PQITLWQRPIVTVKIAGQLKEALFDTGADDTVFQEIHLPGKWKPKLIGGIGGFVKVRQYE QVPIEICGHKVMGPVVVGPTPANVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184I, L210W, T215Y | K70KQ, V75M, F77L | V21VI, V35M, K43KE, E44ED, V118I, D123E, E138A, D177DE, I178M, G196E, Q197EK, T200TA, E203K, H208Y, R211D, K223Q, A272P, K277R, R284K, T286A, E297A, G359S, A376S, S379SC, A400T | K13KR |
| >6228-30807| codons 1-400 PISPIETVPVKLRPGMDGPKIKQWPLTEEKIKALMEICTELEEDGKISKIGPENPYNTPV FAIKKKNSTQWRKLMDLRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYIDDLYVGSDLEIEKHRAKIKELRQYLWDWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLKGAKALTEVIPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEAVQKISTECIVIWGKTPKFKLPIQKETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |