Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6226 | 6226-30730 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215F | N348NI | Y188L | K49KR, S68G, V106I, D123E, I135T, I178L, V179I, V189I, H208Y, R211K, H221HY, A272P, P294T, H315N, S322T, R356RK, G359GA, A360AV, A371AV, K388R | K102LR |
| >6226-30730| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISRIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSITVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLII YQYVDDLLIGSDLEIGQHRTKIEELRQYLWKWGFFTPDKKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVITLTEEAE LELAENREILKEPVNGVYYDPTKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYAKMRAV HTNDVKQLTEVVQKIATESIVIWGKTPRFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, L76V, V82F, L90M | L23I | L10I, I15V, D60E, I62V, L63P, A71V, I93L |
| >6226-30730| codons 1-99 PQITLWQRPIVTIKVGGQLKEAILDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYE QVPIEICGHKVIGTVVVGPTPFNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |