<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6226 6226-30730 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, L76V, V82F, L90M L23I L10I, I15V, D60E, I62V, L63P, A71V, I93L  
>6226-30730| codons 1-99
PQITLWQRPIVTIKVGGQLKEAILDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYE
QVPIEICGHKVIGTVVVGPTPFNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, L210W, T215F N348NI Y188L   K49KR, S68G, V106I, D123E, I135T, I178L, V179I, V189I, H208Y, R211K, H221HY, A272P, P294T, H315N, S322T, R356RK, G359GA, A360AV, A371AV, K388R K102LR
>6226-30730| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISRIGPENPYNTPV
FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSITVLDVGDAYFSVPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLII
YQYVDDLLIGSDLEIGQHRTKIEELRQYLWKWGFFTPDKKYQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVITLTEEAE
LELAENREILKEPVNGVYYDPTKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYAKMRAV
HTNDVKQLTEVVQKIATESIVIWGKTPRFKLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006