Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6225 | 6225-30729 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L10FIV, V11I, K43T, G73S | T4S, T12S, I13IV, I15V, L19P, K20I, M36I, N37ND, D60E, I62V, L63P, A71I, I72R, I93L |
| >6225-30729| codons 1-99 PQISLWQRPVISVKVGGQPIEALLDTGADDTVLEEIDLPGRWTPKIIGGIGGFVKVRQYE QVPIEICGHKIRSTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67~, K70R, L74I, M184V, T215F | T69G, K219E | K103N | V108I | K20R, K43KQ, A98S, K122E, I135T, I167IV, L228H, V245E, A272P, K277R, R284K, T286A, V292I, I293V, Q334N, M357T, G359S, A360T, K366R, A376S, A400S |
| >6225-30729| codons 2-400 ISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEQEGKISKIGPENPYNTPVF AIKKK~SGRWRKIVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTILDVGDAYFSVPLD EDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKVLEPFRKQNPDIVIY QYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFFTPDEKHQKEPPFHWMGYELHPDKWTV QPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLKGAKALTEIVPLTEEAEL ELAENREILKEPVHGVYYDPSKDLIAEIQKQGNGQWTYQIYQEPFKNLKTGKYARTRSTH TNDVRQLTEAVQKISTESIVIWGKTPKFKLPIQKETWES |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |