Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6220 | 6220-30730 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69D, K70R, M184V | D67G, K219Q | K101E | K20R, T39A, V60I, S68G, D123E, I135T, E138A, G196E, F214L, A272P, T286A, E297R, I326V, G335S, M357T, A371V, I375V, T386V, E399D |
| >6220-30730| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAEMEKEGKISKIGPENPYNTPI FAIKKKGGDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGLTTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGQSQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEVVQKVATESIVIWGKVPKFKLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | L10F, V11VI, G73S | T12TS, I13V, L19I, K20I, K43KR, I62V, L63P, A71V |
| >6220-30730| codons 1-99 PQITLWQRPFISVKIGGQIIEALLDTGADDTVLEEMNLPGRWRPKMIGGIGGFIKVRQYD QVPIEICGHKVISTVLVGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |