Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6212 | 6212-30904 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I54S, V82A, I84IV, L90LM | L33F, K43T, T74P | L10I, I13V, K20R, E34Q, M36I, I62V, L63P, H69K, A71V, I93M |
| >6212-30904| codons 1-99 PQITLWQRPIVTVKIGGQLREALLDTGADDTVFQEINLPGRWTPKIIVGIGGFSKVRQYD QVPIEICGKKVIGPVLVGPTPANVIGRNLMTQMGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, Y115F, Q151M, M184V | F116Y, K219Q, N348NI | T27S, E53D, D123E, S162N, F214L, L228LH, V245E, A272P, K277R, K281R, I293V, E297K, M357T, A376V |
| >6212-30904| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTEMEKEGKISKIGPDNPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFYSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQNSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDQKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYARTRGA HTNDVKQLTEAVQKIVTESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |