Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6209 | 6209-30715 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54CST, V82A, I84V | L10I, I13V, I15V, Q18H, K20I, E35D, M36I, N37D, Q61QH, A71I, P79S, Q92K |
| >6209-30715| codons 1-99 PQITLWQRPIVTVKVGGHLIEALLDTGADDTVLEDIDLPGRWKPKMIVGIGGFTKVRQYD HILIEICGHKIIGTVLVGSTPANVIGRNLLTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, T215Y | E28A, V35L, T39A, K43E, E44D, V118I, D123E, T200I, L210S, R211RK, D218E, V245Q, D250E, A272P, A288S, L289I, I293V, E297K, L301I, V317A, I329L, M357A, V365I |
| >6209-30715| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTAEKIKALLEICAELEEDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRIKIEELRQHLSKWGFYTPEKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSITEVVPLTKEAE IELAENREILKEPVHGAYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYARARGA HTNDIKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |